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10mg/vial MT-1 Polypeptide Hormones Raw Powder Melanotan-1 CAS 75921-69-6

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10mg/vial MT-1 Polypeptide Hormones Raw Powder Melanotan-1 CAS 75921-69-6

10mg/vial MT-1 Polypeptide Hormones Raw Powder Melanotan-1 CAS 75921-69-6
10mg/vial MT-1 Polypeptide Hormones Raw Powder Melanotan-1 CAS 75921-69-6 10mg/vial MT-1 Polypeptide Hormones Raw Powder Melanotan-1 CAS 75921-69-6

Large Image :  10mg/vial MT-1 Polypeptide Hormones Raw Powder Melanotan-1 CAS 75921-69-6 Get Best Price

Product Details:
Place of Origin: china manufactuer
Brand Name: steriodshow
Certification: ISO,SGS
Model Number: 75921-69-6
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Price: Negotiate
Packaging Details: Special disguised packaging or as your demand
Delivery Time: within 12hours after payment
Payment Terms: T/T, MoneyGram,
Supply Ability: plent of stock
Detailed Product Description
Name: Melanotan-1 Synonyms: MT-1
Appearance: White Powder Assay: 98%
CAS: 75921-69-6 MF: C78H111N21O19
MW: 1646.845
High Light:

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10mg/vial MT-1 Polypeptide Hormones Raw Powder Melanotan-1 CAS 75921-69-6 

 

 

1. MT-1, Melanotan-1 Details:

 

Name:MT-1, Melanotan-1
Melanotan-1 Peptide Amino Acid Sequence: 
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Molecular formula: C78H111N21O19 
Molar Mass: 1646.845 
CAS number: 75921-69-6 
PubChem: CID 16154396 
Synonyms: Melanotan; Melanotan-1; Melanotan I; CUV1647; EPT1647; NDP-MSH;
[Nle4, D-Phe7]α-MSH 
[Nle4, D-Phe7]-α-MSH Melanotan 
Packing:10mg/vial

 

2. MT-1, Melanotan-1 Specification:

 

TEST    ITEMS    SPECIFICATION    RESULT
1    Appearence    White powder    Conforms
2    Peptide Content    ≥80.0%    81.0%
3    Water (KF)    ≤8.0%    5.8%
4    Acetic Acid    9%~15.0%    10.5%
5    Purity(HPLC)    ≥98.0%    98.3

 

3. MT-1, Melanotan-1 Description:

 

Melanotan I ([Nle4-DPhe7]α-melanocyte-stimulating hormone analog) is a synthetic hormone that is stimulating the release of melanocyte-hormone in animal cells. These melanocyte-hormones are the
ones responsible for the pigmentation of the skin due to their interaction with melanocortin-1 receptors
in the epidermis. These hormones are being released from the pars intermedia of the pituitary glands in some of the eukaryotic animal species. However, these are also prominent in the keratinocytes and the melanocytes of the human skin (Hadley 1982). The molecular structure is shown below:

It was attempted to be extracted from biological matrices such as cell culture transport media and human plasma. This was done by relatively fast and isocratically within 8.0 minutes using the C8 reversed column. In order to successfully isolate the said protein, the mobile phase has been optimized using 0.1 molar of phosphate buffer with 18 μl/l triethylamine at pH 2.50 with an average flow rate of 1 iml/min and being detected at 214 nm. This study have shown that results are very consistent and has already been used in investigating the transport of melanotan-I in the caco-2 cell monolayer model (Surendran et al. 1995).

Studies have shown that in organisms that do not possess fur or thick hair, the superpotent derivative
of the menocyte stimulating hormone which is the melanotan-1 have induced tanning. Furthermore, it
has already been demonstrated that malenotan-1 also induces eumelanin synthesis in the skin of
animals, especially humans which is coincidental with its tanning effect (Dorr et al. 2004). When combined with UV-B light or sunlight, a tanning synergy between these factors was strongly observed. Furthermore, it was shown that when melanotan-1 was combined with sunlight, it produced a long-lasting tan at the
sun-exposed back sites. However, when induced in greater amounts, melanotan-1 has been shown to induce side-effects. In the same study conducted by Dorr et al. (2004), nausea was observed in the experimental units. Possible explanation for this is the interaction of the melanotan-1 with the melanocortin-3 receptors which in turn are found in the gastrointestinal tissues of animals.

The Development of Melanotan 1
The initial creation of the Melanotan 1 peptide tanning analogue can be credited to the University of Arizona. During the course of study aimed at developing a defense against skin cancer, focus was
placed on developing a method of stimulating natural melanogenesis, or the natural production of
melanin in the skin, without direct exposure to the potentially harmful ultraviolet radiation in sunlight. Initially, University of Arizona researchers attempted to directly administer the naturally occurring
hormone alpha-MSH in order to elicit this desired result. Although this strategy exhibited promising

results, it was determined that the naturally occurring MSH had a prohibitively short half-life to be of realistic use as a therapeutic remedy. However, the positive results gleaned from MSH administration encouraged further research into the development of Melanotan 1, which exhibits similar effects
whilst possessing an extended half-life for functional therapeutic utilization. The researchers,
headed by Victor J. Hruby and Mac E. Hadley, found a peptide, [Nle4, D-Phe7]-α-MSH, that was approximately 1,000 times more potent than natural α-MSH. They named this new peptide molecule "Melanotan" (later Melanotan-1).


Melanotan-1 Mechanism of Action - How it Works!
Melanotan produces its photoprotective effects by triggering a 'signaling cascade' via its activation of the MC1R on melanin-producing cells known as melanocytes. Upon Melanotan binding with the MC1R on the surface of melanocytes in the epidermal layer of the skin, it begins a series of actions and reactions that result in melanocytes favoring the production of eumelanin (photoprotective black/brown pigment). The initial binding activates the MC1R leading to the activation of adenylate cyclase (AC) and stimulation of the production of cyclic adenosine monophosphate (cAMP). cAMP in turn activates protein kinase
A (PKA) resulting in the phosphorylation of the cAMP response element-binding (CREB). Phosphorylated CREB will bind to the cAMP response element (CRE) on the microphthalmia-associated transcription factor (MITF) gene leading to the synthesis of the MITF protein. MITF has the ability to activate several genes by binding to them, including the MC1R gene and the genes involved in melanogenesis. This results in increased concentrations of the melanogenic enzymes within the melanocyte.

 

4. Packaging & Delivery


Packing :10mg/Vial
Package Weight :6( Grams )
Delivery Lead Time :Within 24 hours after payment
Minimum Order :10 Vials
Packing methods: Different kinds of special packing methods.
Price:The larger order is,the cheaper price is.Of course, if you want to order samples to test,ok,no problem, the moderate price will be given to you.

Sufficient stock:Sophisticated and professional logistic agent.

Well trained and disciplined packing team:Packing pictures and tacking code are provided within 12 hours after receiving the payment.

Excellent after sale service: Any questions or problems after receiving the product, please feel free to 
contact us. Problems would be solved immediately. 

 

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10mg/vial MT-1 Polypeptide Hormones Raw Powder Melanotan-1 CAS 75921-69-6 0

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