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steroid raw powder,
medicine raw material
Agomelatine CAS 138112-76-2 Anti-Depression Pharmaceutical Raw Materials
1. agomelatine description:
Melting Point:107-109 °C
Boiling point:478.8 °C at 760 mmHg
Competitive price with high quality
Conforms to BP/USP/EP/FCC
|Appearance||White to almost white crystalline powder||white crystalline powder|
|Solubility||This product is soluble in DMF, methanol, ethanol, water and 0.1mol/L hydrochloric acid solution almost not||108.4-108.5 C|
|UV||Has an absorption maximum at 230nm||Conforms|
|IR||Corresponding to reference spectrum||Conforms|
|HPLC||Should the retention time of the main peak of the reference solution||Conforms|
|Impurities I||≤0.1%||Not detected|
|Impurities II||≤0.1%||Not detected|
|Ethyl acetate||≤0.5%||Not detected|
|Loss on drying||≤0.5%||0.002%|
|Residue on ignition||≤0.1%||0.06%|
2. agomelatine Medical uses
Major depressive disorder
Agomelatine is indicated for the treatment of major depressive episodes in adults.Ten placebo controlled trials have been performed to investigate the short term efficacy of agomelatine in major depressive disorder. At the end of treatment, significant efficacy was demonstrated in six of the ten short-term double-blind placebo-controlled studies.Two were considered "failed" trials, as comparators of established efficacy failed to differentiate from placebo. Efficacy was also observed in more severely depressed patients in all positive placebo-controlled studies.The maintenance of antidepressant efficacy was demonstrated in a relapse prevention study.
Results of the meta-analysis of three positive, randomized, double-blind, placebo controlled studies in 357 patients treated with agomelatine and 360 patients treated with placebo show that agomelatine is effective in treating severe depression. Its antidepressant effect is greater for more severe depression. In patients with a greater baseline score (>30 on HAMD17 scale), the agomelatine-placebo difference was of 4.53 points.Controlled studies in humans have shown that agomelatine is at least as effective as the SSRI antidepressants paroxetine, sertraline, escitalopram, venlafaxine and fluoxetine in the treatment of major depression.
A large meta-analysis of 20 trials with 7460 participants found agomelatine to be as effective as standard antidepressants.
A small open-label study has suggested efficacy in the treatment of atypical and melancholic depression.Well-designed clinical trials have demonstrated efficacy in the treatment of anxious depression.Agomelatine’s onset of action has been reported to occur as early as the first week of treatment.
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B. Best price, first class service, high successful delivery rate. A discount would be given when you make
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C. High quality guarenteed, once any problem is found, the package would be reshipped for you
D. Shipping by express (FedEx,UPS,DHL,EMS TNT HKEMS), by air.The most professional forwarder
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E. Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.Adhering to the principle of customer first conviction.we will provide the best and the most
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