SBS BIOTECH CO.,LTD

 

          Steroid Powders,Sarms,Peptides Supplier

 

 

Home
Products
About Us
Factory Tour
Quality Control
Contact Us
Request A Quote
News
Home ProductsPolypeptide Hormones

Amino Acid Peptides IGF-1 LR3 for Increased Biological Activity CAS 946870-92-4

I'm Online Chat Now
China SBS BIOTECH CO.,LTD certification
your powder really good,brother, order again soon

—— James

Perfect powder ,my clients like so much,really assist my business Clara

—— John

Everything is fantastic.You have the best packaging i have ever dealt with!Provided powder is very good,i'm very pleased to work with you!

—— Mike

——

Amino Acid Peptides IGF-1 LR3 for Increased Biological Activity CAS 946870-92-4

Amino Acid Peptides IGF-1 LR3 for Increased Biological Activity CAS 946870-92-4
Amino Acid Peptides IGF-1 LR3 for Increased Biological Activity CAS 946870-92-4 Amino Acid Peptides IGF-1 LR3 for Increased Biological Activity CAS 946870-92-4

Large Image :  Amino Acid Peptides IGF-1 LR3 for Increased Biological Activity CAS 946870-92-4 Get Best Price

Product Details:
Place of Origin: China
Brand Name: Skype: rdy705
Certification: Enterprise Standard
Model Number: ycwlb045@yccreate.com
Payment & Shipping Terms:
Minimum Order Quantity: 10vials
Price: USD1
Packaging Details: Disguised Package
Delivery Time: Within 24 hours
Payment Terms: T/T, MoneyGram,
Supply Ability: 50000000
Detailed Product Description
Peptide Content: ≥99% CAS: 946870-92-4
Water Content: ≤5.0% Acetate Content: ≤15.0%
Purity: 99%min. Properties: Powder
Payment: T/T, , MoneyGram, Bitcoin Delivery Time: Within 24 Hours
Delivery Mode: EXPRESS Door To Door
High Light:

natural steroid hormones

,

peptides for bodybuilding

Amino Acid Peptides IGF-1 LR3 for Increased Biological Activity CAS 946870-92-4

 

WHAT IS IGF-1 LR3?


IGF-1 LR3, also known as Long Arg3 IGF-1, is a recombinant protein analogue of human Insulin-Like Growth Factor-1 that has a molar mass of 9,200 Daltons and is comprised of 83 amino acids. IGF-1 LR3 comprises the complete IGF-1 sequence, but with a 13 amino acid extension on the B-Terminus domain and the substitution of an Arginine for the Glutamic Acid at position 3. The LR3 analogue of IGF-1 was created with the intent to drastically increase the biological activity of the protein and IGF-LR3 is several times more potent than rhIGF-1. This specific sequence alteration has decreased the affinity of binding to the IGFBPs, which control the biological actions of IGF-1 and prevent the protein from reaching the IGF-1 receptors.

 

IGF-1 LR3 is an 83 amino acid analogue of human IGF-1 that has been modified to include a 13 amino acid extension on its N-Terminus and the substitution of an Arginine amino acid for Glutamine at position 3. While IGF-1 LR3 is comprised of the the complete human IGF-1 sequence, these modifications have rendered the LR3 version to be much more potent than IGF-1 in-vitro and in-vivo. The result of these modifications is that IGF-1 LR3 does not bind as strongly to the IGFBPs, which modify the biological actions of IGF-1. Resultantly, IGF-1 LR3 binds to the type 1 IGF-1 receptor with similar affinity to that of wild type IGF-1, but with higher biological activity and has several advantages over recombinant insulin. The supplementation of mammalian cell cultures with Long R3 IGF-1 at a much lower concentration results in more highly elevated productivity than with standard concentrations of insulin and/or standard IGF-1. IGF-1 LR3 is better able to stimulate the type 1 IGF receptor and thus induce a higher level of activation of intracellular signaling, which is responsible for promoting cell proliferation and the inhibition of apoptosis.

 

What is the Amino Acid Sequence of IGF-1 LR3?


The amino acid sequence (three letter) is Met-Phe-Pro-Ala-Met-Pro-Leu-Ser-Ser-Leu-Phe-Val-Asn-Gly-Pro-Arg-Thr-Leu-Cys-Gly-Ala-Glu-Leu-Val-Asp-Ala-Leu-Gln-Phe-Val-Cys-Gly-Asp-Arg-Gly-Phe-Tyr-Phe-Asn-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Gln-Thr-Gly-Ile-Val-Asp-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Glu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala

 

Receptor Grade vs Media Grade IGF-1 LR3


Genuine Receptor Grade LR3 IGF-I is a high quality research reagent for use in studies on cell growth, IGF receptors and IGF binding proteins and is more potent than rH IGF-1 and Media Grade IGF-1 LR3 both in vivo and in vitro due to the drastic increase in biological activity (stronger affinity for binding with the IGF receptor) and high-level purity. This combination of increased biological activity and purity is what sets Receptor Grade IGF-1 LR3 apart from standard IGF-1. Media grade LR3 IGF-I is more commonly used in commercial cell culture vs mammalian. It can also be used as a research reagent at an economical cost to enable studies where biological potency is of less value and higher quantities are required. To maximize results in an animal-based cell study or production Receptor Grade IGF-1 Long R3 should be used exclusively.


IGFB Binding and Increased Biological Activity


By resisting IGFBP-binding, IGF-1 LR3 has a greater physiologic effect than IGF-1 does. The longer duration of action allows for smaller amounts to be used with the same effects. Some IGF-1 derivatives, such as the GPE derivative, made up of just the last three N-terminal amino acids of the IGF-1 protein, have been shown to have therapeutic effects in neurological injuries like stroke. Most studies concerning the effects of IGF-1 derivatives have been carried out in animal models, with little to no data available for humans.


Insulin Like Growth Factor Receptor Interactions


IGF-1 Long R3 binds to at least two cell surface receptors: IGF-1R and the insulin receptor. The IGF-1 receptor is referred to as the "physiologic" receptor because IGF-1 binds to it with significantly higher affinity (approximately 100 times higher) than it does to the insulin receptor. By binding to IGF-1R, IGF-1 can affect metabolism, cell growth (hypertrophy), differentiation and cell division (hyperplasia), prevention of cell death (apoptosis), normal development, and even malignant growth. IGF-1R has been implicated in several different types of cancer include breast, prostate, and lung cancer. IGF-1 also binds to the insulin receptor and activates it, thereby encouraging cells to take up glucose from the blood stream. The effects of IGF-1 on muscle cells are three-fold. Firstly, IGF-1 encourages hyperplasia, or an increase in the number of muscle cells. Secondly, IGF-1 has a strong effect on skeletal muscle - In regards to the life span of satellite cells. Satellite cells support muscle cells, providing them with needed nutrients and helping them to operate efficiently. 
 

Related Steroids Hormone Powder:

Testosterone Boldenone MGF
Testosterone Acetate Boldenone Acetate PEG MGF
Testosterone Cypionate Boldenone undecyl(Equipoise) CJC-1295
Testosterone Decanoate Boldenone Propionate CJC-1295 DAC
Testosterone Enanthate Boldenone Cypionate PT-141
Testosterone Isocaproate Nandrolone Melanotan-1
Testosterone Phenylpropionate Nandrolone Decanoate Melanotan-2
Testosterone Propionate Nandrolone phenylpr(Durabolin) GHRP-2
Testosterone Undecanoate Nandrolone undecylate GHRP-6
Methyltestosterone Nandrolone cypionate  Ipamorelin
Formestane Nandrolone propionate Hexarelin
4-Chlorodehydromethyltestosterone Tibolone Sermorelin
Clostebol Acetate Trenbolone Oxytocin
Fluoxymesterone Trenbolone Acetate TB500
Testosterone Sustanon 250 Trenbolone Enanthate HGH 176-191
Mestanolone Methyltrienolone Triptorelin
Stanolone Trenbolone Hexahydrobenzyl Tesamorelin
Mesterolone(Proviron) 7-keto DHEA Gonadorelin
Methenolone Enanthate Dehydroisoandrosterone (DHEA) DSIP 
Methenolone Acetate Oxymetholone (Anadrol) Selank
Methyldrostanolone(Superdrol) Oxandrolone (Anavar) BPC 157
Drostanolone Propionate(Masteron) Stanozolol (Winstrol) Orlistat
Drostanolone Enanthate Methandienone (Dianabol)  Ostarine(MK-2866)
Tamoxifen Citrate(Nolvadex) Sildenafil citrate Andarine(S4)
Clomifene citrate Sildenafil Mesylate GW501516
Toremifene citrate Tadalafil, Cialis RAD140
Exemestane  hydrochloride SR9009
Anastrozole Vardenafil YK11
Letrozole Dutasteride MK-677
Androstadiendione Avanafil LGD4033
Androstenedione Acetildenafil AICAR
Methoxydienone Sunifiram
Megestrol Finasteride Pirfenidone
Methylepitiostanol (Epistane) Yohimbine hydrochloride TUDCA
Estra-4,9-diene-3,17-dione Eplerenone 5a-hydroxy laxogenin
Stenbolone 1-Testosterone Adrafinil
Cabergoline Gestodene PHENIBUT
Rimonabant Estradiol enantate Carphedon
Mebolazine Dexamethasone Sodium Phosphate FASORACETAM
Mibolerone Trestolone acetate NSI-189
Mifepristone Chlormadinone acetate IDRA 21/AMPAKINE
Misoprostol Estriol Pikamilone
Ethynyl estradiol 17alpha-Oestradiol  COLURACETAM
Ethisterone 17a-Methyl-1-testosterone Aegelin
L-liothyronine(T3) Hydroxyprogesterone Demethyl
Trendione(Trenavar) Norandrostenedione   
Altrenogest Estradiene dione-3-keta  
TACROLIMUS 4-Androsten-3b-ol-17-one Contact: Ivy Young
Tamoxifen Androst-4-ene-3,6,17-trione Skype: rdy705
Vardenafil HCL 6-bromoandrostenedione Mobile: +8618578209860
17beta-Estradiol T4 Sodium Salt WhatsApp: +8618578209860
Estrone Estradiol benzoate ycwlb045@yccreate.com


Amino Acid Peptides IGF-1 LR3 for Increased Biological Activity CAS 946870-92-4 0

Contact Details
SBS BIOTECH CO.,LTD

Contact Person: Alex

Tel: 86-18171373082

Send your inquiry directly to us