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BMS907351 Anticancer Raws Cabozantinib CAS 849217-68-1 for Only Reseach Usage

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BMS907351 Anticancer Raws Cabozantinib CAS 849217-68-1 for Only Reseach Usage

BMS907351 Anticancer Raws Cabozantinib CAS 849217-68-1 for Only Reseach Usage
BMS907351 Anticancer Raws Cabozantinib CAS 849217-68-1 for Only Reseach Usage BMS907351 Anticancer Raws Cabozantinib CAS 849217-68-1 for Only Reseach Usage BMS907351 Anticancer Raws Cabozantinib CAS 849217-68-1 for Only Reseach Usage

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Product Details:
Place of Origin: China
Brand Name: Skype: rdy705
Certification: Enterprise Standard
Model Number: ycwlb045@yccreate.com
Payment & Shipping Terms:
Minimum Order Quantity: 1G
Price: USD1
Packaging Details: Disguised Package
Delivery Time: Within 24 hours
Payment Terms: T/T, MoneyGram,
Supply Ability: 50000000
Detailed Product Description
CAS: 849217-68-1 MF: C28H24FN3O5
MW: 502 Source: Synthetic
Purity: 99%min. Properties: Powder
Payment: T/T, , MoneyGram, Bitcoin Delivery Time: Within 24 Hours
Delivery Mode: EXPRESS Door To Door
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BMS907351 Anticancer Raws Cabozantinib CAS 849217-68-1 for Only Reseach Usage

 

Product Name: Cabozantinib
Synonyms: N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;Cabozantinib;N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide;XL184;Cabozantinib(XL184);XL-184 free base (Cabozantinib);BMS907351;N-(4-((6,7-DiMethoxyquino...
CAS: 849217-68-1
MF: C28H24FN3O5
MW: 502

 

Cabozantinib Anti-cancer drugs

 

Cabozantinib is a kind of a novel type of molecular targeted drugs developed by the United States Exelixis biopharmaceutical company. On November 29, 2012, the US Food and Drug Administration (FDA) approved the use of cabozantinib for the treatment of unresectable malignant local advanced or metastatic medullary thyroid carcinoma.
In addition, Sorafenib, Vandernib and Levotinib have been approved by the Food and Drug Administration (FDA) for the treatment of advanced thyroid cancer

.

Cabozantinib Mechanism of action

 

In vitro biochemical and / or cytological analysis have shown that cabozantinib can inhibit the tyrosine kinase activity of RET, human hepatocyte growth factor receptor (MET), vascular endothelial growth factor receptor 1 (VEGFR- 1, VEGFR-2, VEGFR-3, stem cell factor receptor (KIT), receptor kinase receptor (TRKB), FMS-like tyrosine kinase- 3, FLT-3), AXL and human tyrosine kinase with immunoglobulinlike and EGF-like domains 2, TIE-2. All the above kinase receptors play an important role in the growth of normal cells and tumor cells. The abnormal expression of these receptors is critical in the development and progression of many kinds of tumors, including the inhibition of tumor cell apoptosis, participating into the tumor angiogenesis and invasion and other pathological processes. Cabozantinib exerts its antitumor effect by inhibiting the above kinase activity, killing tumor cells, reducing metastasis and inhibiting tumor angiogenesis.

 

Cabozantinib Usage

 

Usage XL184 (Cabozantinib, BMS-907351) is a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively.
Usage Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively

 

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