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DFS Fine Chemicals Deferasirox / Exjade CAS 201530-41-8 for Intermediate Usage

DFS Fine Chemicals Deferasirox / Exjade CAS 201530-41-8 for Intermediate Usage

  • DFS Fine Chemicals Deferasirox / Exjade CAS 201530-41-8 for Intermediate Usage
  • DFS Fine Chemicals Deferasirox / Exjade CAS 201530-41-8 for Intermediate Usage
  • DFS Fine Chemicals Deferasirox / Exjade CAS 201530-41-8 for Intermediate Usage
DFS Fine Chemicals Deferasirox / Exjade CAS 201530-41-8 for Intermediate Usage
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CAS: 201530-41-8 MF: C21H15N3O4
MW: 373.3615 Source: Synthetic
Purity: 99%min. Properties: Powder
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DFS Fine Chemicals Deferasirox / Exjade CAS 201530-41-8 for Intermediate Usage

 

Product Name: Deferasirox
Synonyms: 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid;deferasirox;Benzoic acid, 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-;Deferasirox for research;4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic Acid;CGP-72670;Exjade;ICL-670
CAS: 201530-41-8
MF: C21H15N3O4
MW: 373.3615

 

Deferasirox Uses

 

1. DFS can be used to treat the reversible renal insufficiency caused by Fanconi syndrome.
2. It can be used for the treatment of secondary hemochromatosis.
3. It can be used for the treatment of delayed skin porphyria.
4. It can be used for the treatment of myelodysplastic syndromes.
5. It can be used for the treatment of iron overloading caused by blood transfusion for patients (older than 2 years old) of chronic anemia This information is compiled and edited by Ding Hong of Chemicalbook. (2015-09-18)
Precautions Patients with allergy to deferasirox are disabled.
Chemical Properties White to Off-White Solid
Usage Orally active tridentate iron chelator
Usage Biological Activity Chemical Information Tech Support & FAQs Biological Activity Deferasirox(Exjade) is a rationally-designed oral iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions
Usage A tridentate chelator that binds iron with high affinity
Usage Labeled Deferasirox, intended for use as an internal standard for the quantification of Deferasirox by GC- or LC-mass spectrometry.

 

Deferasirox Pharmacological effects

 

DFS has antifungal activity (such as Mucor growing in the iron-rich environment), anti-cell proliferation, anti-malaria, anti-oxidative stress injury, anti-cytotoxicity induced apoptosis and other pharmacological effects.
1. DFS and fungal infection
Iron is a substance that fungi rely on, and plays a very important role in the growth and toxicity of fungi. The antifungal effect of iron chelator may be due to their effect of removal of the iron necessary for fungal growth, so as to achieve the purpose of treatment of fungal infection.
2. DFS and cell proliferation
Iron plays a very important role in the process of cell proliferation. Iron chelators may have anti-proliferative properties, suggesting that iron chelators may be a novel anticancer agent for the treatment of tumors.

 

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