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High Purity Prohormones Steroids Misoprostol CAS 59122-46-2 for Terminate Pregnancy
Product Name: Misoprostol
Synonyms: CYTOTEC;9-OXO-11ALPHA,16-DIHYDROXY-16-METHYL-PROST-13E-EN-1-OIC ACID;9-OXO-11ALPHA,16-DIHYDROXY-16-METHYL-PROST-13E-EN-1-OIC ACID, METHYL ESTER;(11A,13E)-(-)-11,16-DIHYDROXY-16-METHYL-9-OXO-PROST-13-EN-1-OIC ACID METHYL ESTER;(11alpha,13e)-(+)-11alpha,16-dihydroxy-16-methyl-9-oxoprost-13e-en-1-oic acid methyl ester;(+/-)-15-DEOXY-[16RS]-16-HYDROXY-16-METHYLPROSTAGLANDIN E1;(+/-)-15-DEOXY-(16R,S)-16-HYDROXY-16-METHYL-PROSTAGLANDIN E1, METHYL ESTER;SC-29333
Chemical Properties White Solid
Usage antiulcerative;prostaglandin E1 analog that inhibits gastric acid secretion
Usage A cytoprotective prostaglandin PGE1 analogue
Biological Activity Cytoprotective prostaglandin E 1 analog that displays agonist activity at EP receptors. K i values are 120, 250, 67 and 67 nM at cloned mouse EP 1 , EP 2 , EP 3 and EP 4 receptors respectively. Prevents NSAID-induced gastric ulceration.
Misoprostol is approved for use in the prevention of NSAID-induced gastric ulcers. It acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell. Because other classes of drugs, especially H2-receptor antagonists and proton pump inhibitors, are more effective for the treatment of acute peptic ulcers, misoprostol is only indicated for use by people who are both taking NSAIDs and are at high risk for NSAID-induced ulcers, including the elderly and people with ulcer complications. Misoprostol is sometimes coprescribed with NSAIDs to prevent their common adverse effect of gastric ulceration (e.g. with diclofenac in Arthrotec).
Misoprostol has other protective actions, but is only clinically effective at doses high enough to reduce gastric acid secretion. For instance, at lower doses, misoprostol may stimulate increased secretion of the protective mucus that lines the gastrointestinal tract and increase mucosal blood flow, thereby increasing mucosal integrity. However, these effects are not pronounced enough to warrant prescription of misoprostol at doses lower than those needed to achieve gastric acid suppression.
However, even in the treatment of NSAID-induced ulcers, omeprazole proved to be at least as effective as misoprostol,but was significantly better tolerated, so misoprostol should not be considered a first-line treatment. Misoprostol-induced diarrhea and the need for multiple daily doses (typically four) are the main issues impairing compliance with therapy.
The most commonly reported adverse effect of taking a misoprostol orally for the prevention of stomach ulcers is diarrhea. In clinical trials, an average 13% of patients reported diarrhea, which was dose-related and usually developed early in the course of therapy (after 13 days) and was usually self-limiting (often resolving within 8 days), but sometimes (in 2% of patients) required discontinuation of misoprostol.
The next most commonly reported adverse effects of taking misoprostol orally for the prevention of gastric ulcers are: abdominal pain, nausea, flatulence, headache, dyspepsia, vomiting, and constipation, but none of these adverse effects occurred significantly more often than when taking placebos. In practice, fever is almost universal when multiple doses are given every 4 to 6 hours.
Misoprostol should not be taken by pregnant women to reduce the risk of NSAID-induced gastric ulcers because it increases uterine tone and contractions in pregnancy, which may cause partial or complete abortions, and because its use in pregnancy has been associated with birth defects.
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