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Pharmaceutical Ingredients Acitretin CAS 55079-83-9 for Antipsoriatic Usage

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Pharmaceutical Ingredients Acitretin CAS 55079-83-9 for Antipsoriatic Usage

Pharmaceutical Ingredients Acitretin CAS 55079-83-9 for Antipsoriatic Usage
Pharmaceutical Ingredients Acitretin CAS 55079-83-9 for Antipsoriatic Usage Pharmaceutical Ingredients Acitretin CAS 55079-83-9 for Antipsoriatic Usage Pharmaceutical Ingredients Acitretin CAS 55079-83-9 for Antipsoriatic Usage

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Product Details:
Place of Origin: China
Brand Name: Skype: rdy705
Certification: Enterprise Standard
Model Number: ycwlb045@yccreate.com
Payment & Shipping Terms:
Minimum Order Quantity: 1G
Price: USD1
Packaging Details: Disguised Package
Delivery Time: Within 24 hours
Payment Terms: T/T, MoneyGram,
Supply Ability: 50000000
Detailed Product Description
CAS: 55079-83-9 MF: C21H26O3
MW: 326.43 EINECS: 259-474-4
Purity: 99%min. Properties: Powder
Payment: T/T, , MoneyGram, Bitcoin Delivery Time: Within 24 Hours
Delivery Mode: EXPRESS Door To Door
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Pharmaceutical Ingredients Acitretin CAS 55079-83-9 for Antipsoriatic Usage


Product Name: Acitretin
Synonyms: (all-e)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraen;6,8-nonatetraenoicacid,3,7-dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-4;all-trans-3,7-dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetra;all-trans-etretin;retinoidetretin;ro10-1670;(E)-9-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-3,7-DIMETHYL-2,4,6,8-NONATETRAENOIC ACID;etretin
CAS: 55079-83-9
MF: C21H26O3
MW: 326.43
EINECS: 259-474-4

 

Acitretin Usage And Synthesis


Chemical Properties Crystalline Solid
Usage A synthetic retinoid which is the major metabolite of etretinate (E938000).
Usage antipsoriatic;binds to nuclear receptors that regulate gene transcription

 

Acitretin (trade names Soriatane and Neotigason) is a second-generation retinoid. It is taken orally, and is typically used for psoriasis.

It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days. However, because acitretin can be reverse metabolised into etretinate which has an extremely long half-life, women must avoid becoming pregnant for at least 3 years[1] after discontinuing acitretin. Therefore, acitretin is generally not recommended for women of child-bearing age with a risk of becoming pregnant.

Acitretin is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects it is generally used in only very severe cases of psoriasis that have been unresponsive to other treatments. It binds to nuclear receptors that regulates gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia, leading to the slowing of cell reproduction. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after 2 to 4 weeks or longer.

Patients that have received the medication are advised against giving blood for at least 3 years due to the risk of birth defects.

 

Acitretin  Adverse effects


Acitretin is noted for the possibility of severe birth defects and should not be used by pregnant women or women planning to get pregnant within 3 years following the use of acitretin. Sexually active women of childbearing age who use acitretin should also use at least 2 forms of birth control concurrently. Men and women who use it should not donate blood for 3 years after using it, because of the possibility that the blood might be used in a pregnant patient and cause birth defects. In addition, it may cause nausea, headache, itching, dry, red or flaky skin, dry or red eyes, dry or chapped lips, swollen lips, dry mouth, thirst, cystitis acne or hair loss.

 

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