Payment & Shipping Terms:
|Payment::||T/T, , Moneygram,bitcoin||Export Markets:||Global|
|Molecular Weight:||404.93||Quality Standards:||USP28|
|Express:||EMS, DHL, FedEx, Etc(door-to-door)||Einecs:||206-118-0|
|Melting Point:||128-132 Degree Centigrade||Boiling Point:||447.2 Degree Centigrade At 760 Mmhg|
|Flash Point:||166.7 Degree Centigrade|
steroid raw powder,
medicine raw material
Chlormadinone Acetate Synonyms: 17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione; 17-Acetoxy-6-chloro-6-dehydroprogesterone; 17-alpha-Acetoxy-6-chloro-6,7-dehydroprogesterone; 17-alpha-acetoxy-6-chloro-6-dehydroprogesterone; 17alpha-Acetoxy-6-chloro-6-dehydroprogesterone; 17-alpha-acetoxy-6-chloropregna-4,6-diene-3,20-dione; 17alpha-Acetoxy-6-chloropregna-4,6-diene-3,20-dione; 20-dione,17-(acetoxy)-6-chloro-pregna-6-diene-3
Chlormadinone Acetate CAS: 302-22-7
Chlormadinone Acetate MF: C23H29ClO4
Chlormadinone Acetate MW: 404.93
Chlormadinone Acetate EINECS: 206-118-0
Chlormadinone Acetate Chemical Properties Crystalline Solid
Chlormadinone Acetate Usage Orally active progesteron with antiandrogenic activity; Has been used in combinations as an oral contraceptive. Progestogen; Antineoplastic (hormonal)
Chlormadinone Acetate Usage tranquilizer, neuroleptic, alpha adrenergic blocker
Chlormadinone acetate (INN, USAN, BAN, JAN;Sold under brand names including Clordion, Gestafortin, Lormin, Non-Ovlon,Normenon, Verton, and many others) (CMA) is a derivative of progesterone (17α-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961 and is used as an orally effective progestogen in hormone replacement therapy (HRT), and in combination with ethinyl estradiol (EE) in contraception since 1999. Chlormadinone acetate has a strong progestogenic effect - about one-third higher than that of progesterone - and may vary depending on the previous effect of an estrogen, i.E., estrogens may promote the formation of progesterone receptors and proliferation of the endometrium. Like progesterone, it is anti-estrogenic and has no partial androgenic effect (at the doses used for contraception and HRT). In contrast to progesterone, it has a slight glucocorticoid effect, a pronounced anti-androgenic effect and no anti-mineralocorticoid effect.No pregnancy-maintaining effect of CMA has been demonstrated in humans.
The anti-androgenic effect of CMA is presumed to be the result of both its binding to androgen receptors - competitively inhibiting the effect of endogenous testosterone and dihydrotestosterone - and the competitive inhibition of 5α-reductase.In this respect, dosing of CMA is crucial;Agonistic effects are observed when doses are increased from those optimal for an antagonistic effect.
Chlormadinone acetate is a steroidal progestin with additional antiandrogen andantigonadotropic (and thus also antiestrogenic) effects.It is used clinically as a hormonal contraceptive, and in part due to its lowering of estrogen levels, but also for improved effectiveness in contraception, chlormadinone is frequently combinedwith ethinyl estradiol for this purpose.
Chlormadinone acetate has a strong anti-gonadotropic effect, through negative feedback on gonadotropin secretion, and has been used for more than 20 years alone for contraception in arterial risk patients. The clinical and metabolic tolerability of CMA has been demonstrated in numerous clinical studies with duration of treatment of up to 2.5 years.
|Estradiol valerate||Estriol||Hydrocortisone acetate|
|Estradiol cypionate||Diethylstilbestrol||Prednisone acetate|
|Algestone acetophenide||Medroxyprogesterone acetate||Clobetasol propionate|
|Lynestrenol||Allylestrenol||Prednisolone phosphate sodium|
|Chlormadinone acetate||Dienogestrel||Fluorometholone Acetate|
|Cyproterone acetate||Drospirenone||Dexamethasone Acetate|
|Megestrol acetate||Pregnenolone||Dexamethasone Sodium Phosphate|
|Melengestrol acetate||Mometasone furoate||Dexamethasone palmitate|
|Betamethasone acetate||Beclomethasone dipropionate||Fluocinolone acetonide|
|Betamethasone Dipropionate||Betamethasone 17-valerate|
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