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ZD6474 Fine Chemicals Vandetanib CAS 443913-73-3 for Anticancer

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ZD6474 Fine Chemicals Vandetanib CAS 443913-73-3 for Anticancer

China ZD6474 Fine Chemicals Vandetanib CAS 443913-73-3 for Anticancer supplier
ZD6474 Fine Chemicals Vandetanib CAS 443913-73-3 for Anticancer supplier ZD6474 Fine Chemicals Vandetanib CAS 443913-73-3 for Anticancer supplier ZD6474 Fine Chemicals Vandetanib CAS 443913-73-3 for Anticancer supplier

Large Image :  ZD6474 Fine Chemicals Vandetanib CAS 443913-73-3 for Anticancer

Product Details:

Place of Origin: China
Brand Name: Skype: rdy705
Certification: Enterprise Standard
Model Number: ycwlb045@yccreate.com

Payment & Shipping Terms:

Minimum Order Quantity: 1G
Price: USD1
Packaging Details: Disguised Package
Delivery Time: Within 24 hours
Payment Terms: T/T, Western Union, MoneyGram and Bitcoin
Supply Ability: 50000000
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Detailed Product Description
CAS: 443913-73-3 MF: C22H24BrFN4O2
MW: 475.35 Source: Synthetic
Purity: 99%min. Properties: Powder
Payment: T/T, Western Union, MoneyGram, Bitcoin Delivery Time: Within 24 Hours
Delivery Mode: EXPRESS Door To Door

 

ZD6474 Fine Chemicals Vandetanib CAS 443913-73-3 for Anticancer

 

Product Name: Vandetanib
Synonyms: VANDETANIB;4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-;Vandetanib for research;4-(4-Bromo-2-fluoroanilino)-6-methoxy- 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline;N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine;Zactima;ZD 6474;7-((4-aminocyclohexyl)methoxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine
CAS: 443913-73-3
MF: C22H24BrFN4O2
MW: 475.35

 

Vandetanib Anticancer drugs

 

Vandetanib is a kind of small molecule multi-targeted tyrosine kinase inhibitor studied and developed by the British AstraZeneca Company. In April 2011, it was approved the US FDA for entering into market under the trade name Zactima. The drug, as a tablet, can be applied to the treatment of advanced medullary thyroid cancer of adult patients.
Vandetanib is a multi-targeted tyrosine kinase inhibitor, and belongs to the Anilinoquinazoline compounds, called "second generation Iressa”. It not only acts on the tumor cells, EGFR, VEGFR and RET tyrosine kinases, but can also inhibit other kind of tyrosine kinases and serine / threonine kinases. Vandetanib is the first approved drugs approved for treatment of medullary thyroid carcinoma. It is suitable for treating unresectable, locally advanced or metastatic-symptoms or progressive medullary thyroid carcinoma. A randomized, placebo-controlled clinical trial results have showed that vandetanib can significantly delay the progression time of locally advanced or metastatic medullary thyroid cancer. The recommended daily dose is 300 mg (oral), when the patient exhibits tolerance to drugs or being not able to tolerate the toxicity, they should stop treatment immediately. Those most common adverse reactions of this medicine include diarrhea, rash, acne, nausea, hypertension, headache, fatigue, loss of appetite and abdominal pain. The adverse reactions is dose-related; at <300 mg/d, the patient has a well tolerance with the maximum tolerated dose (MTD) being 300mg. There are many kinds disease types contained in the Ⅱ phase clinical study. The NSCLC clinical trials of vandetanib are currently under way for China.
British AstraZeneca Company, in May 2001 and October 2001, respectively, had obtained preferential access to the world's patent (WO2001032651, WO 2001074360) and applied corresponding protection on the formula, synthesis methods and pharmaceutical compositions of these compounds (including bonus salt). Vandetanib can inhibit the development of medullary thyroid carcinoma, and is the first FDA-approved drug for the treatment of the disease and will provide support for the treatment of advanced medullary thyroid cancer in adult patients.

 

Vandetanib Usage And Synthesis

 

Chemical Properties Yellow Solid
Usage Vandetanib (Zactima, ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
Usage Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM
Usage Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor kinase activity. The activity of Vandetanib plus Docetaxel was assessed in patients with previously treated non-small-cell lung cancer (NSCLC).

 

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ZD6474 Fine Chemicals Vandetanib CAS 443913-73-3 for Anticancer

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