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Zhuhaishi Shuangbojie Technology Co.,ltd

Good quality Anabolic Androgenic Steroids for sales
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Acadesine/AICAR/AICA-RIBOSIDE/AMPK/Z-RIBOSIDE polypeptide hormone CAS: 2627-69-2

China Acadesine/AICAR/AICA-RIBOSIDE/AMPK/Z-RIBOSIDE  polypeptide hormone  CAS: 2627-69-2 supplier
Acadesine/AICAR/AICA-RIBOSIDE/AMPK/Z-RIBOSIDE  polypeptide hormone  CAS: 2627-69-2 supplier Acadesine/AICAR/AICA-RIBOSIDE/AMPK/Z-RIBOSIDE  polypeptide hormone  CAS: 2627-69-2 supplier

Large Image :  Acadesine/AICAR/AICA-RIBOSIDE/AMPK/Z-RIBOSIDE polypeptide hormone CAS: 2627-69-2

Product Details:

Place of Origin: china manufactuer
Brand Name: steriodshow
Certification: SGS,ISO9001,UKAS
Model Number: ycwlb053@yccreate.com

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiable
Packaging Details: Special disguised packaging or as your demand
Delivery Time: within 12hours after payment
Payment Terms: Western Union, MoneyGram, T/T,Bitcoin
Supply Ability: plent of stock
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Detailed Product Description
Assay: 98% CAS Register Number: 2627-69-2
Molecular Formula: C9H14N4O5 Molecular Weight: 258.23
Appearance:: White Or White Crystal Company Name: Zhuhai Shuangbojie Technology Co,.Ltd
Payment Terms:: Western Union, MoneyGram, T/T,Bitcoin Delivery Time:: Within 12hours After Payment
Packing: Special Disguised Packaging Or As Your Demand Alias:: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE

1.product  description

Quick Detail:
Acadesine
Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE 
CAS: 2627-69-2 
EINECS: 220-097-5 
Molecular Formula: C9H14N4O5 
Molecular Weight: 258.23 
Assay: 98% 
Apperance: White or off-white powder. 
Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases


Functions:
AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
 
AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.
 
 
Biological Activity:
AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. 
 
Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro.  
 
 
Specification:
 


Item

Specification

Result

Appearance

 
White powder

Complies

Related substance (HPLC)

Total impurity ≤0.5%
Max single impurity ≤0.1%

0.2%
0.06%

Odor

Characteristic

Complies

Assay

99%

99.8%

Sieve analysis

100% pass 80 mesh

Complies

Loss on Drying
Residue on Ignition

≤1.0%
≤1.0%

0.12%
0.09%

Heavy Metal

<10ppm

Complies

As

<0.1ppm

0.05ppm

Pb

<0.1ppm

0.05ppm

Cd

<0.1ppm

0.05ppm

Residual Solvents

<100ppm

Complies

Residual Pesticide

Negative

Complies

Microbiology

 

 

Total Plate Count

<1000cfu/g

Complies

Yeast & Mold

<100cfu/g

Complies

E.Coli

Negative

Complies

Salmonella

Negative

Complies


 

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The information you want to know
1.Payment terms:Western Union, MoneyGram, T/T,Bitcoin
2.Delivery Time:within 12hours after payment
3.Supply Ability:Plenty in Stock
4.Packing:Special disguised packaging or as your demand
5.Delivery:EMS, DHL, FedEx, Express courier.
6.available  tracking numble:
           EA057277290CN
           EA223108200HK
           EA224146399HK
           367294163 TNT
           EA224167283HK
           EA237467692HK
           EA118582471HK
 

 

 

 

About us
Zhuhaishi Shuangbojie Technology Co., Ltd, a leading manufacturer and supplier of pharmaceutical intermediates and polypeptide  in China, is located in Zhuhai City  Guangdong Province.Our company's various chemical raw material produtshave stable and reliable quality, it is mainly sold to pharmacy 

company and health care company in abroad, like USA, Canada, UK, Brazil,Netherlands, Ireland,New Zealand, Austria,Australia and so on.  

Our company will take high-quality  products, the most preferential  prices and the most considerate service for your satisfaction.  We look forward to opportunities for business cooperation with you
 

Acadesine/AICAR/AICA-RIBOSIDE/AMPK/Z-RIBOSIDE  polypeptide hormone  CAS: 2627-69-2

Why choose us
Everything     just     for        you  
Contact  me :  Skype:IVY3029 Marin
                          Cell :+8618578209867
 
 

Our advantages 

 

 High quality with competitive price
1) Standard: Enterprise Standard
2) We are manufacturer and can provide high quality products with factory price. 
3) Quality can be promised. Hot sell to Worldwide.
 
 Fast and safe delivery
1)  Parcel can be sent out in 24 hours after payment. Tracking number available
2)  Secure and discreet shipment. Various transportation methods for your choice. 
3)  We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in 

there for transferring. 
4)  Tracking your order at any time. Inform your order's further new situation at any time.
 
Our clients throughout the world. 
1)  Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their 

desire. 
2)  Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility. 
3)  High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers. 


 
 
 
 
 
 

 

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