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4-DHEA is a naturally occurring DHEA isomer. It's structure closely resembles regular DHEA but the double bond in the 4th position dramatically changes its effects. 4-DHEA has many health benefits over standard 5-DHEA since it may not have intrinsic estrogenic activity. This means that men and women, who are already overloaded with environmental estrogens from things like BPA and pesticides, can enjoy the health benefits of DHEA without adding to their estrogen load.
Alias: 4-DHEA, 4-AD, 4-Dehydroepiandrosterone, 4 androstene-3b-ol, 17-one, 4-androstenediol
Appearance: White Crystalline Powder
Method of Analysis: HPLC
200-500mg/day when stacked
Average Cycle Length:
4-DHEA may reduce muscle loss as we age without the negative effects of standard DHEA therapy. This means that people who use DHEA will want to talk to their naturopath or doctor about the benefits of these new forms of DHEA such as 4-DHEA and others.
4-DHEA may appear under the nomenclature 4-androstene-3b-ol, 17-one. 4-DHEA does not have much anabolic activity on its own, but it converts to testosterone in a two-step process involving the enzymes 3bHSD and 17bHSD. 4-DHEA first converts to androstenediol and androstenedione and then to testosterone. 4-DHEA is best used during mass gaining phases rather then during dieting phases, as it is considered to be a “wet” prohormone that is associated with mass gains that come with some temporary bloating.
4-DHEA readily converts to 4-androstenediol, rather than 5-androstenediol, boosting its anabolic potency more than 2x over regular DHEA. (6-8, 11) 4-DHEA is also expected to have a higher conversion rate to testosterone compared to regular DHEA. (6, 7) The 4-DHEA also lacks the calorie burning thermogenic properties, therefore offering superior calorie retention for a bulking effect. (4) This increased anabolic potency and reduced thermogenic action will lead to noticeable gains in strength, lean tissue growth, and weight gain.
Less side effect:
The estrogenic side effects of 4-DHEA have been significantly reduced in comparison to DHEA. 4-DHEA can convert to estrogen but it cannot act directly in the estrogen receptor like DHEA, so any estrogenic side effects experienced with 4-DHEA use are a result of increased estrogen levels only.
As with the other DHEA isomers, 4-DHEA is naturally occurring and non-toxic. Side-effects such as oily skin or reduced fertility are considered mild and temporary. The most notable side-effect would be suppression of natural testosterone production, which makes post cycle therapy necessary after a cycle. Overall 4-DHEA is a very safe and effective lean muscle building agent.
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