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Anti-Obesity Drug AOD9604 Peptide Lyophilized Powder AOD-9604 2mg/vial CAS 221231-10-3
AOD 9604 2mg/vial
AOD-9604 is a peptide fragment which a tyrosine is added at the N-terminus. Studies have suggested that AOD-9604 is more effective than its predecessor AOD-9401 in its ability to stimulate lipolytic and anti-lipogenic activity. AOD-9604 stimulates lipolysis (the breakdown of fat) and inhibits lipogenesis (prevents the transformation of fatty food materials into body fat) both in laboratory testing and in animals. In laboratory tests on fat cells from rodents, the fragment released fat specifically from obese fat cells and reduced new fat accumulation in all fat cells.
Purity, Formulation & Physical Appearance
GHPeptides™ AOD-9604 has a peptide purity level that exceeds 99.0% as determined by HPLC. This peptide was synthesized with no additives and is supplied as a white lyophilized (freeze-dried) powder.
The Development of AOD9604 from Human Growth Hormon
Investigators at Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the GH molecule. This region, which consists of amino acids 177-191, is less than 10% of the total size of the GH molecule and appears to have no effect on growth or insulin resistance. It works by mimicking the way natural Growth Hormon regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified Growth Hormon.
In laboratory tests on fat cells from rodents, pigs, dogs, and humans, the fragment released fat specifically from obese fat cells but not from lean ones, reduced new fat accumulation in all fat cells, enhanced the burning of fat. In rodents (rats and mice), fragment reduced body fat in obese animals but, enhanced fat burning without changing food consumption or inducing growth (as it does not increase IGF levels) or any other unwanted Growth Hormon effect. Recent research has shown AOD9604 to be an extremely potent and effective fat burner. Metabolic is developing AOD-9604 for the potential treatment of obesity. Research studies have shown that AOD9604 actually acts on the reduction of excessive adipose tissues such as those in the abdominal area, increase in muscle mass, and enhances the lipid content of the body.
These segments of the synthetic peptide AOD9604 have been researched for their in vivo effects in laboratory mice musculus. Results have shown that AOD9604 have resulted to a short-period increase in blood glucose and a more sustained increase in plasma insulin, together with other fragments such as 172-191, 177-191 and 178-191. In addition, the researchers have suggested that functionality of the peptide depends not only in the informational sequence but should also have the correct physical configuration (Ng and Borstein 1978). Also, AOD9604, being a region of high accessibility to proteases and also rich in proline, have been demonstrated to affect the conformational change in the cytoplasmic domain of the band 3 of erythrocyte membrane protein by serving as the hinge for the pivoting of the two subdomains. This then suggest that such residue is significant in conformational changes be serving as sites for peripheral protein binding in some body cells (Low et al. 1984).
Solubility & Storage
It is recommended to reconstitute the lyophilized AOD-9604 in sterile water, which can then be further diluted in other aqueous solutions. Lyophilized AOD-9604 although stable at room temperature for 3-4 weeks, should be stored desiccated below -18°C. Upon reconstitution, AOD-9604 should be stored at 4°C out of direct light for between 10-14 days and for future use below -18°C. Prevent repeated freeze-thaw cycles.
This product has been synthesized for in-vitro laboratory studies to be performed with cells or biological molecules. This product is not a drug and has not been approved by the FDA to prevent or cure any medical condition or disease. The purchaser is solely liable for risk involved with using this product for any purpose outside of in vitro studies.
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