Payment & Shipping Terms:
|Apperance:||White Powder||Delivery Time:||Within 24h After Confirm Your Payment|
|Payment Terms:||Western Union,Moneygram,tt,Bitcoin||Express:||UPS,TNT,DHL,EMS,HKEMS,FEDEX|
pharma raw materials,
steroid raw powder
Pharmaceutical Raw Material Ketoconazole for Antifungal Treatment CAS 65277-42-1
Apperance:White Crystalline Powder
Delivery Time:Within 24 Hours Upon Receipt of Payment
Payment:Western Union, Money Gram, T/T,Bitcoin
Package:Discreet Package to Pass The Custome
1.Ketoconazole is an antifungal medication that fights infections caused by fungus.
2.Ketoconazole is not for use in treated fungal infections of the fingernails or toenails. This medicine is also not for use in treating prostate cancer or Cushing syndrome.This medicine should be used only when you cannot use other antifungal medications.
3.Ketoconazole can cause serious harm to your liver that may result in liver transplant or cause death.
4.Ketoconazole may also be used for purposes not listed in this medication guide.
|Items of analysis||Specification||Results|
|Appearance||A white or almost white powder.||Qualified|
|Specific rotation||-1º~ +1º
|Loss on drying||≤0.5%
|Residue on ignition||≤0.1%
ketoconazole belongs to azole-class antifungal drugs and has antifungal activity against various kinds of genus of deep fungal infections such as Candida, Fonsecaea, Coccidioides, Histoplasma, Sporothrix spp as well as Trichophyton. However, this product has a relative weak activity against Aspergillus, Sporothrix schenckii as well as some species of Dermateaceae and Mucor.
This product, through actively interfering with the activity of cytochrome P-450, is capable of inhibiting the biosynthesis of the major steroids - ergosterol of the fungal cell membrane. Therefore, it destroys the fungal cell membrane and changes its permeability, resulting in the leakage of important intracellular material.
Ketoconazole can also inhibit the biosynthesis of fungal triglyceride and phospholipid biosynthesis, inhibit the activity of oxidase and peroxidase, causing accumulation of intracellular hydrogen peroxide which further leads to cell submicroscopic structural degeneration and necrosis. For candida albicans, it can also suppress the transition process from spores to aggressive mycelium.
Toxicology: Long-term animal toxicity experiments have showed that ketoconazole can significantly increase the level of alkaline phosphatase and cause liver cell degeneration.
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