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|Product Name:||Ethynyl Estradiol||Usage:||Used As Pharmaceutical Raw Material|
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Ethynyl Estradiol CAS 57-63-6 Anti Estrogen Steroids for Female Health Care
Product Name: Ethynyl Estradiol
refractive index: -30 ° (C=0.4, Pyridine)
storage temp: -20°C Freezer
solubility ethanol: 50mg/mL, clear, slightly yellow
Ethinyl Estradiol description
1.Ethinyl Estradiol is hormonally effective by activating the estrogen receptor and thus is an estrogen. It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives.
2.Ethinyl Estradiol is absorbed in the small intestine and reaches a serum peak about 2 hours later. It undergoes extensive metabolism in the liver involving the cytochrome P450 3A4 isoenzyme. Ethinyl Estradiol and its metabolites are excreted with the bile. Due to the effect of enterohepatic circulation a second peak is seen several hours later. Individually, wide variations exist in the overall absorption process, and can be further modified by drugs that affect the enterohepatic circulation or liver enzymes. In circulation Ethinyl Estradiol is almost fully bound to plasma albumin. It is metabolized by hydroxylation of the aromatic ring and excreted in both feces and urine, in part as glucuronide and sulfate conjugate.
1.It is a combination drug that contains female hormones that prevent ovulation (the release of an egg from an ovary). This medication also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.
2.It is used as contraception to prevent pregnancy.
3.It may also be used for purposes not listed in this medication guide.
|Items of analysis||
|Appearance||White to creamy white, odorless, crystalline powder||white crystalline powder|
|Solubility||Insoluble in water; soluble in alcohol, in chloroform, in ether,in vegetable oils, and in solutions of fixed alkali hydroxides.||Conforms|
|Specific optical rotation||-28°u65374X -29.5°||-29°|
|Loss on drying||≤1.0%||0.29%|
|Residual Solvents||Acetone≤5000ppm;Ethanol≤5000ppm;||235ppm;No Detectable;No Detectable|
|Assay||97.0~102.0% (on the dried basis)||99.5%|
|Particle Size||90% ≤10μ||Conforms|
Ethynyl estradiol Application:
Ethinyl estradiol (EE), also sometimes written as ethinylestradiol, ethynyl
estradiol, or ethinyl estradiol, is aderivative of 17 beta-estradiol (E2), the major endogenous estrogen in humans. EE is an orally bioactive estrogen used in many formulations of combined oral contraceptive pills. It is one of the most
commonly used medications for this purpose.
Transdermal ethinyl estradiol carries a greater risk of clot formation and venous thromboembolism than naturally occurring 17β-estradiol, which some have theorized
to be related to different amounts of hepatic metabolism after absorption. The same contraindications and precautions apply for EE as with other estrogen medications.
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