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Active Pharmaceutical Ingredients Pizotifen CAS 15574-96-6 for Appetite Stimulant

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CAS 15574-96-6 MF C19H21NS
MW 295.44 EINECS 239-632-9
Purity 99%min. Properties Powder
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Product Description

 

Active Pharmaceutical Ingredients Pizotifen CAS 15574-96-6 for Appetite Stimulant

 

Product Name: Pizotifen
Synonyms: 4-OXO-9,10-DIHYDRO-4H-BENZO(4,5) CYCLOHEPTO(1,2,B) THIOPHENE;PIZOTIFEN;4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine;BC 105;bc105;Litec;Piperidine, 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methyl-;piperidine,4-(9,10-dihydro-4h-benzo(4,5)cyclohepta(1,2-b)thien-4-ylidene)-1-me
CAS: 15574-96-6
MF: C19H21NS
MW: 295.44
EINECS: 239-632-9

 

Pizotifen Usage And Synthesis


Chemical Properties White to Off-White Solid
Usage benzocycloheptane based drug
Usage Serotonin antagonist structurally related to Cyproheptadine. Antimigraine; appetite stimulant.

 

Pizotifen Uses

 

The main medical use for pizotifen is for the prevention of vascular headache including migraine and cluster headache. Pizotifen is one of a range of medications used for this purpose, other options include propranolol, topiramate, valproic acid and amitriptyline. While pizotifen is reasonably effective,[2] its use is limited by side effects, principally drowsiness and weight gain, and it is usually not the first choice medicine for preventing migraines, instead being used as an alternative when other drugs have failed to be effective.[3] It is not effective in relieving migraine attacks once in progress. Pizotifen has also been reported as highly effective in a severe case of erythromelalgia, a rare neurovascular disease that is sometimes refractory to the other drugs named above.[4]

Other applications for which pizotifen may be used include as an antidepressant, or for the treatment of anxiety or social phobia.[5][6] Animal studies also suggest that pizotyline could be used in the treatment of serotonin syndrome or MDMA overdose[7] in a similar manner to the closely related antihistamine/antiserotonin drug cyproheptadine.

 

Pizotifen Adverse effects

 

Side effects include sedation, dry mouth, drowsiness, increased appetite and weight gain.[8] Occasionally it may cause nausea, headaches, or dizziness. In rare cases, anxiety, aggression and depression may also occur.

 

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Active Pharmaceutical Ingredients Pizotifen CAS 15574-96-6 for Appetite Stimulant 0