 |
| Place of Origin: | china manufactuer |
| Brand Name: | steriodshow |
| Certification: | ISO,SGS |
| Model Number: | 13647-35-3 |
| Minimum Order Quantity: | 10g |
|---|---|
| Price: | Negotiate |
| Packaging Details: | Special disguised packaging or as your demand |
| Delivery Time: | within 12hours after payment |
| Payment Terms: | T/T, , |
| Supply Ability: | plent of stock |
| Name: | Trilostane | Synonyms: | Modrenal |
|---|---|---|---|
| CAS: | 13647-35-3 | EINECS: | 237-133-0 |
| MF: | C20H27NO3 | MW: | 329.43 |
| Appearance: | Tan Crystals | Assay: | 99% Min |
| High Light: | anti estrogen drugs,natural anti estrogen |
||
Anti-Estrogen Steroid Raw Powder Trilostane For Breast Cancer Treatment CAS 13647-35-3
1. Trilostane Description:
Name:Trilostane
Synonyms: (2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;
4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;
4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;
4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril
CAS: 13647-35-3
MF: C20H27NO3
MW: 329.43
EINECS: 237-133-0
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
Chemical Properties: Tan Crystals
Usage: An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment
of breast cancer . antifungal, inhibits mitosis in metaphase .
Packing:1kg/foil bag or as required
2. Trilostane Usage:
Trilostane can suppress cortical hormone synthesis process of 3 beta dehydrogenase, make cortisol, aldosterone synthesis reduce, clinical used in the treatment of Cushing syndrome(cortisol increase disease) and primary aldosteronism,the effect is not good than testosterone metyrapone. This product has significantly reduced blood testosterone level role, may relevant to its inhibit synthetic.
3. Trilostane Features:
Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase, which plays a role in adrenal steroid biosynthesis. Investigators believe that Arg195 in 3β-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 3β-HSD, but not 3β-HSD2
by Trilostane. Research shows that trilostane is effective in suppressing the intracellular production oin LNCaP-FGC prostate cancer cells and inhibiting cortisol biosynthesis in the human adrenal gland. This product serves as a useful tool in steroid biosynthesis research.
4. Trilostane Specifications:
|
Test Items |
Specification |
Test Results |
|
|
Appearance |
white oralmost white,crystalline powder |
Conform |
|
|
Solubility |
Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride. |
Conform |
|
|
Identification |
A |
The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64. |
Conform |
|
|
B |
Infraed absorption spectrophotometry. |
Conform |
|
|
C |
Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution. |
Conform |
|
|
D |
An orange-red color develop in methylene chloride layer. |
Conform |
|
|
E |
It geves reaction (a) of sulphates. |
Conform |
|
Appearance of solution |
Solution S is clear and not more intensely coloured than reference solution in BY6. |
Conform |
|
|
Optical rotation |
negative 0.10° to +0.10°determined on solution S. |
+0.01° |
|
|
Acidity or alkalinity |
NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red. |
Conform |
|
|
Related substances |
Impurity J ≤0.20% |
Conform |
|
|
|
Any other impurity ≤0.30% |
Conform |
|
|
|
Total impurity ≤1.0% |
Conform |
|
|
Boron |
≤50ppm |
Conform |
|
|
Sulphated ash |
≤0.10% |
0.06% |
|
|
Loss on drying |
≤0.5% |
0.30% |
|
|
Assay(on dried basis) |
98.0~101.0% |
99.5% |
|
5. Our Advantages:
We are back to introduce us to more clients again! Actually, we are in the business as a professional
raw material lab supplier for over 15 years, we have more than enough experience to handle everything
in the right way.
a. Our products did & do be shipped safely to many countries with mass quantity always.
b. We do get professional team, esp., for package & shipment, do have strong connection in shipping system, all the parcels are sent via traceable couriersas UPS, FedEx, DHL & so on, do offer customs clearance guaranteed to the destination country.
c. Products are in prompt stock, chargeable samples are available at any time,can be shipped out immediately upon the requirement.
d. You get the absolutely right choice if want the best stuff & service, high quality,good price, fast and safety delivery guaranteed, we do have reshipping policy once anyuncontrollable incident happens.
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Tel: 86-18171373082
