Place of Origin: | China |
Brand Name: | Skype: rdy705 |
Certification: | Enterprise Standard |
Model Number: | ycwlb045@yccreate.com |
Minimum Order Quantity: | 1G |
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Price: | USD1 |
Packaging Details: | Disguised Package |
Delivery Time: | Within 24 hours |
Payment Terms: | T/T, , |
Supply Ability: | 50000000 |
CAS: | 755037-03-7 | MF: | C21H15ClF4N4O3 |
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MW: | 482.8154128 | Source: | Synthetic |
Purity: | 99%min. | Properties: | Powder |
Payment: | T/T, , , Bitcoin | Delivery Time: | Within 24 Hours |
Delivery Mode: | EXPRESS Door To Door | ||
High Light: | pharma raw materials,steroid raw powder |
Pharmaceuticals Regorafenib CAS 755037-03-7 for Research Purposes Only
Product Name: Regorafenib
Synonyms: Regorafenib;BAY 73-4506;4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide;BAY 73-4506(Regorafenib);4-[4-({[4-chioro-3-(trifluoroMethyl)phenyl]carbaMoyl}aMino)-3-fluorophenoxy]-pyridine-2-carboxylic acid MethylaMide;Regorafenib (BAY 73-4506);4-[4-[[[[4-Chloro-3-(trifluoroMethyl)phenyl]aMino]carbonyl]aMino]-3-fluorophenoxy]-N-Methyl-2-pyridinecarboxaMide;4-[4-[N'-(4-Chloro-3-trifluoroMethylphenyl)ureido]-3- fluorophenoxy]pyridine-2-carboxylic Acid MethylaMide
CAS: 755037-03-7
MF: C21H15ClF4N4O3
MW: 482.8154128
Regorafenib Usage And Synthesis
Usage It inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.
Usage BAY 73-4506 (Regorafenib) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.
Usage Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively
Regorafenib Adverse effects
Regorafenib is being approved with a Boxed Warning alerting patients and health care professionals that severe and fatal liver toxicity occurred in patients treated with regorafenib during clinical studies. Serious side effects, which occurred in less than one percent of patients, were liver damage, severe bleeding, blistering and peeling of skin, very high blood pressures requiring emergency treatment, heart attacks and perforations (holes) in the intestines. The most common side effects reported in patients treated with regorafenib include weakness or fatigue, loss of appetite, hand-foot syndrome (also called palmar-plantar erythrodysesthesia), diarrhoea, mouth sores (mucousitis), weight loss, infection, high blood pressure, and changes in voice volume or quality (dysphonia).
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