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Pharma Inhibitors Powder GSK2118436 / Dabrafenib CAS 1195765-45-7 for Anticancer

  • Pharma Inhibitors Powder GSK2118436 / Dabrafenib CAS 1195765-45-7 for Anticancer
  • Pharma Inhibitors Powder GSK2118436 / Dabrafenib CAS 1195765-45-7 for Anticancer
  • Pharma Inhibitors Powder GSK2118436 / Dabrafenib CAS 1195765-45-7 for Anticancer
Place of Origin China
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Model Number ycwlb045@yccreate.com
Minimum Order Quantity 1G
Price USD1
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Product Details
CAS 1195765-45-7 MF C23H20F3N5O2S2
MW 519.5624096 Source Synthetic
Purity 99%min. Properties Powder
Payment T/T, , , Bitcoin Delivery Time Within 24 Hours
Delivery Mode EXPRESS Door To Door
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Product Description

 

Pharma Inhibitors Powder GSK2118436 / Dabrafenib CAS 1195765-45-7 for Anticancer

 

Product Name: Dabrafenib (GSK2118436)
Synonyms: Dabrafenib;N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide;Dabrafenib free base(GSK2118436A);Dabrafenib (GSK2118436);GSK2118436A;Dabrafenib (GSK2118436A);Dabrafenib KB-57246;Debrafenib API
CAS: 1195765-45-7
MF: C23H20F3N5O2S2
MW: 519.5624096

 

Dabrafenib Description:

 

Dabrafenib (trade name Tafinlar, GSK2118436) is a drug for the treatment of cancers associated with a mutated version of the gene BRAF. Dabrafenib acts as an inhibitor of the associated enzyme B-Raf, which plays a role in the regulation of cell growth. Dabrafenib has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma.[1][2]

The Food and Drug Administration initially approved dabrafenib as a single agent treatment for patients with BRAF V600E mutation-positive advanced melanoma on May 30, 2013.[3] Clinical trial data demonstrated that resistance to dabrafinib and other BRAF inhibitors occurs within 6 to 7 months.[4] To overcome this resistance, the BRAF inhibitor dabrafenib was combined with the MEK inhibitor trametinib.[4] On January 8, 2014, the FDA approved this combination of dabrafenib and trametinib for BRAF V600E/K-mutant metastatic melanoma.

 

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Pharma Inhibitors Powder GSK2118436 / Dabrafenib CAS 1195765-45-7 for Anticancer 0

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