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Amorolfine HCL / Amorolfine Hydrochloride CAS 78613-38-4 for Experimental Use

  • Amorolfine HCL / Amorolfine Hydrochloride CAS 78613-38-4 for Experimental Use
  • Amorolfine HCL / Amorolfine Hydrochloride CAS 78613-38-4 for Experimental Use
  • Amorolfine HCL / Amorolfine Hydrochloride CAS 78613-38-4 for Experimental Use
Place of Origin China
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Product Details
CAS 78613-38-4 MF C21H36ClNO
MW 353.97 Source Synthetic
Purity 99%min. Properties Powder
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Product Description

 

Amorolfine HCL / Amorolfine Hydrochloride CAS 78613-38-4 for Experimental Use

 

Product Name: Amorolfine hydrochloride
Synonyms: AMOROLFINE HCL;Amorolfine HCI;Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, (2R,6S)-rel-;Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, cis-;Ro 14-4767/002;(+/-)-cis-2,6-Dimethyl-4-[2-methyl-3-(p-tert-pentylphenyl)propyl]morpholine hydrochloride;Amorolfine hydrochloride;(2R,6S)-rel-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine, hydrochloride (1:1)
CAS: 78613-38-4
MF: C21H36ClNO
MW: 353.97

 

Amorolfine hydrochloride Usage And Synthesis


Chemical Properties Liquid
Usage antihypertensive

 

Amorolfine Description:

 

Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits Δ14-sterol reductase and cholestenol Δ-isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine hydrochloride as the active ingredient. It is used to treat onychomycosis (fungal infection of the toe- and fingernails). Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications has been shown in two studies to be between 60% and 71% effective in treating toenail onychomycosis; complete cure rates three months after stopping treatment (after six months of treatment) were 38% and 46%. However, full experimental details of these trials were not available and since they were first reported in 1992 there have been no subsequent trials.[1]

It is a topical solution for the treatment of toenail infections. Systemic treatments may be considered more effective.

It is approved for sale over-the-counter in Australia, Russia and the UK (recently re-classified to over-the-counter status), and is approved for the treatment of toenail fungus by prescription in other countries. It is not approved for the treatment of onychomycosis in the United States or Canada, but can be ordered from there by mail from other countries.

 

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