Place of Origin: | china manufactuer |
Brand Name: | SBS |
Certification: | Enterprise Standard |
Model Number: | 3562-63-8 |
Minimum Order Quantity: | 10g |
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Price: | USD1 |
Packaging Details: | Special disguised packaging or as your demand |
Delivery Time: | within 12hours after payment |
Payment Terms: | T/T, , |
Supply Ability: | plent of stock |
CAS: | 3562-63-8 | MF: | C22H30O3 |
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MW: | 342.47 | EINECS: | 222-628-6 |
Purity: | 99%min. | Properties: | Powder |
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Female Raw Steroid Hormone Megestrol for Orally Progestogen CAS 3562-63-8
Megestrol
Product Name: Megestrol
Synonyms: 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione;20-dione,17-hydroxy-6-methyl-pregna-6-diene-3;4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE;17-ALPHA-HYDROXY-6-METHYL-4,6-PREGNADIENE-3,20-DIONE;MEGESTROL;17-alpha-hydroxy-6-methylpregna-4,6-diene-3,20-dione;Megestrol (base and/or unspecified salts);C07120
CAS: 3562-63-8
MF: C22H30O3
MW: 342.47
EINECS: 222-628-6
Chemical Properties White Solid
Usage Megestrol is an orally active progestogen. Megestrol is used in combinations as oral contraceptive and as antineoplastic agent.
Megestrol Description :
Megestrol acetate (INN, USAN, BAN, JAN) (abbreviated as MGA or MA, and sold mainly under the brand names Megace and Megace ES), also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects.
Though sometimes referred to simply as megestrol, it is important to clarify that megestrol acetate is not the same as megestrol, which is a closely related but different compound.
Megestrol acetate has powerful antiandrogenic and antiestrogenic effects in humans at sufficient doses, capable of decreasing circulating androgen and estrogen concentrations to castrate levels in both sexes and significantly lowering the expression of the androgen receptor (AR) and the estrogen receptor (ER) in the body.
As an example, one study in men with benign prostatic hyperplasia who were treated with 120-160 mg of megestrol acetate per day for 3 to 11 days found average decreases in AR quantity of 73% and 86% in the cytoplasm and nucleus of prostatic cells, respectively.These actions are likely the result of a strong activation of the PR, which suppresses the secretion of the gonadotropins-peptide hormones responsible for signaling the body to produce not only progesterone but also the androgens and the estrogens-from the pituitary gland as a form of negative feedback inhibition, and hence downregulates the hypothalamic-pituitary-gonadal (HPG) axis, resulting in decreased levels of the sex hormones and their associated enzymes, carriers (e.g., sex hormone-binding globulin), and receptors.It is the antiandrogenic and antiestrogenic effects of megestrol acetate mediated by suppression of the HPG axis that are believed to be largely responsible for its beneficial effects against androgen and estrogen-sensitive cancers, respectively.
Megestrol Application :
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