Place of Origin: | china manufactuer |
Brand Name: | steriodshow |
Certification: | Enterprise Standard |
Model Number: | ycwlb045@yccreate.com |
Minimum Order Quantity: | 10g |
---|---|
Price: | USD1 |
Packaging Details: | Special disguised packaging or as your demand |
Delivery Time: | within 12hours after payment |
Payment Terms: | T/T, , |
Supply Ability: | 50000000 |
CAS: | 109581-93-3 | MF: | C44H69NO12 |
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MW: | 822.04 | EINECS: | N/A |
Purity: | 99%min. | Properties: | Powder |
Payment: | T/T, , , Bitcoin | Delivery Time: | Within 24 Hours |
Delivery Mode: | EXPRESS Door To Door | ||
High Light: | steroid raw powder,medicine raw material |
High Purity Pharmaceutical Raw Material Tacrolimus CAS 109581-93-3 for Immune Suppressant
TACROLIMUS
Product Name: TACROLIMUS
Synonyms: FK-506;,8s*,9e,12r*,14r*,15s*,16r*,18s*,19s*,26ar*))-;18-tetramethyl-8-(2-propenyl)-,monohydrate,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*;3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-9,10,12,;tacrolimushydrate;tsukubaenolidehydrate;FK-506 MONOHYDRATE;Tacarolimus
CAS: 109581-93-3
MF: C44H69NO12
MW: 822.04
Usage immune suppressant, antifungal
Biological Activity Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC 50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC 50 = 1 nM), IL-3, IL-4, IL-6 (IC 50 = 35 nM), GM-CSF, TNF α (IC 50 = 10 nM), IFN γ and Myc from activated T-cells in vitro . Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo .
TACROLIMUS Applications:
heart liver kidney and bone marrow transplant patients preferred immune-suppressing drugs after the transplant rejection resistant to conventional immunosuppressive regimen, is also the choice of the drug... Adverse reactions similar to cyclosporine. autoimmune eye disease and other autoimmune diseases also play an active role.
TACROLIMUS Specifications:
Test
|
Specification
|
Result
|
Description
|
A white crystalline powder
|
Complies
|
Solubility
|
Soluble in Methanol, Ethyl acetate and Chloroform
|
Complies
|
Water
|
≤3.0% |
1.3% |
Residue on ignition
|
≤0.10% |
Complies
|
Heavy metals
|
<10ppm |
Complies
|
Isomer
|
≤5.0% |
0.56% |
Individual Impurity
|
≤0.5% |
0.33% |
T otalimpurities
|
≤2.0% |
0.43% |
Assay ( on dry basis including isomers)
|
≥98.0% |
99.8% |
Conclusion
|
The product conforms to the Enterprise specification.
|
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