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Pharmaceutical Raw Steroid Powders Levonorgestrel CAS 797-63-7 for Progestin

Place of Origin china manufactuer
Brand Name SBS
Certification Enterprise Standard
Model Number 797-63-7
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Product Details
CAS 797-63-7 MF C21H28O2
MW 312.45 EINECS 212-349-8
Purity 99%min. Properties Powder
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Product Description

 

Pharmaceutical Raw Steroid Powders Levonorgestrel CAS 797-63-7 for Progestin

 

Levonorgestrel

Product Name: Levonorgestrel 
Synonyms: 13-ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one;13-ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one;13-ethyl-17-hydroxy-19-dinor-17-alpha-pregn-4-en-20-yn-3-on(+)-1;17-alpha-ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one;17-beta-hydroxy-18-methyl-19-nor-17-alpha-pregn-4-en-20-yn-3-one;17-ethynyl-18-methyl-19-nortestosteron;17-ethynyl-18-methyl-19-nortestosterone;18-methyl-17-alpha-ethynyl-19-nortestosterone 
CAS: 797-63-7 
MF: C21H28O2 
MW: 312.45 
EINECS: 212-349-8 

Chemical Properties White Solid 
Usage An emergency contraceptive. Levonorgestrel is safe, tolerated and effective in emergency contraception in woman 
Usage progestin

 

Levonorgestrel Usage

 

Levonorgestrel is used in emergency contraceptive pills(ECPs), both in a combined Yuzpe regimenwhich includes estrogen, and as a levonorgestrel-only method. The levonorgestrel-only method uses levonorgestrel 1.5mg (as a single dose or as two 0.75mg doses 12 hours apart) taken within 3 days of unprotected sex, with one study indicating that beginning as late as 120 hours (5 days) after intercourse could be effective.
The primary mechanism of action of levonorgestrel as a progestogen-only emergency contraceptive pill is, according to FIGO, to prevent fertilization by inhibition of ovulation. The International Federation of Gynecology and Obstetrics(FIGO) has issued a statement that: "review of the evidence suggests that LNG [levonorgestreol] ECPs cannot prevent implantation of a fertilized egg. Language on implantation should not be included in LNG ECP product labeling." In June 2012, a New York Timeseditorial called on the Food and Drug Administration(FDA) to remove from the label the unsupported suggestion that levonorgestrel emergency contraceptive pills inhibit implantation. In November 2013, the European Medicines Agency(EMA) approved a change to the label for HRA Pharma's NorLevo saying it cannot prevent implantation of a fertilized egg. In November 2013, the EMA also approved a change to the label for HRA Pharma's NorLevo saying: "In clinical trials, contraceptive efficacy was reduced in women weighing 75 kg [165 pounds] or more, and levonorgestrel was not effective in women who weighed more than 80 kg [176 pounds]." In November 2013 and January 2014, the FDA and the EMA said they were reviewing whether increased weight and body mass index(BMI) reduce the efficacy of emergency contraceptives.

 

Levonorgestrel Specification:

 

Items

Specification

Results

Description

White or practically white crystalline powder

White crystalline powder

Specific Rotation

30°~-35°

32°

Melting Range

232~239°C, and melting range is not more then 4°C

234~238°C

identification

It complies with the test for specific optical rotation and melting point

Conforms

 

Infrared absorption spectrophotometry should be consistent with levonorgestrel CRS

Conforms

Loss on drying

≤0.5%

0.20%

Residue on ignition

≤0.3%

0.07%

Limit of Ethynyl Group

7.81%~8.18%

7.92%

Related substances

Single impurity ≤0.5%

single impurity<0.5%

 

Total Impurities ≤2.0%

Total impurities<2.0%

Organic Volatile impurties

Ethanol ≤5000ppm

1200ppm

Assay

The product complies with specification in USP34

Particle Size

D(0.9)<10μm

Storage Condition

Sealed, protect from light

 
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Our Service:
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Our advantage:
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4. Delivery: We have products in stock, and we will deliver them soon when your PO arrived. Meanwhile we will give you the tracking number in order to make you know the exact location of the products. We will keep track of the product until they arrive you; We choose the best courier service for you, and with the delivery around 5-7 working days. 
5. Service: Best Service with after-sales service and consultation

 

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