Place of Origin: | steroidraw@chembj.com |
Brand Name: | whatsapp:+8618578209857 |
Certification: | SGS,ISO9001,UKAS |
Model Number: | 52-01-7 |
Minimum Order Quantity: | 10g |
---|---|
Price: | Negotiation |
Packaging Details: | Special disguised packaging or as your demand |
Delivery Time: | within 12hours after payment |
Payment Terms: | T/T, , |
Supply Ability: | 1000 Kilogram/Kilograms per Month |
Product Name: | Spironolactone | English Synonyms: | Aldactone;Antisterone;spirolactone;7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta- Carbolactone |
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CAS: | 52-01-7 | Formula: | C24H32O4S |
MW: | 416.5735 | Assay: | 98.99% |
Appearance: | White Or Almost White Fine Crystalline Powder | Usage: | Used As A Diuretic |
High Light: | pharma raw materials,medicine raw material |
Pharmaceutical Grade Steroids Diuretic Powder Potassium-Sparing Diuretics Spironolactone
1. Spironolactone Quick Detail:
English name: Spironolactone
Synonym: Aldactone;Antisterone;spirolactone;7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,
17-beta- carbolactone
CAS: 52-01-7
EINECS Number: 200-133-6
Formula: C24H32O4S
MW: 416.5735
Molecular Structure:
Density: 1.24g / cm3
Melting point: 198-207 ℃ (dec.)
Boiling point: 597 ° C at 760 mmHg
Flash Point: 302.2 ° C
Water-soluble: practically insoluble
Vapor Pressure: 3.24E-14mmHg at 25 ° C
Melting point 198-207 ° C (dec.)
Specific rotation -37 ° (c = 1, CHCl3)
Water-soluble practically insoluble
Assay:98.99%
Appearance: White or almost white fine crystalline powder
Uses:Used as a diuretic
2. Spironolactone Description:
Spironolactone and commonly shortened simply to "spiro") ,marketed mainly under the brand name
Aldactone in most countries, is a synthetic, steroidal antimineralocorticoid,antiandrogen, and, to a
lesser extent, progestin. It belongs to a class of pharmaceutical drugs known as potassium-sparing diuretics, and is used primarily as a diuretic and antihypertensive in the treatment of heart
failure andhypertension. As a secondary use, spironolactone is also frequently employed off-label
for the purpose of reducing elevated or unwanted androgen levels and activity in the body, such
as in the treatment of hyperandrogenism in women and, especially, as a component of hormone
replacement therapy for trans women.
4. Spironolactone COA:
ITEMS |
STANDARDS |
RESULTS |
Appearance (Ph.Eur.) |
A white or yellowish-white powder |
White powder |
Solubility (Ph.Eur.) |
Practically insoluble in water, soluble in ethanol (96%) |
Complies |
Identification |
||
A. IR –spectrum (Ph.Eur.) |
Meet the requirement |
Complies |
A. IR –spectrum (USP) |
Meet the requirement |
Complies |
B. TLC (Ph.Eur.) |
Meet the requirement |
Complies |
B. UV absorption (USP) |
Meet the requirement |
Complies |
C. Colour reaction (Ph.Eur.) |
Meet the requirement |
Complies |
C. Precipitate reaction (USP) |
Meet the requirement |
Complies |
Specific optical rotation |
-41°~-46° |
-42.8° |
(Ph.Eur.) |
-41°~-45° |
-42.9° |
(USP) |
|
|
Sulphated ash (Ph.Eur.) |
≤0.1% |
0.00% |
Related substances (Ph.Eur.) |
||
Impurity A |
≤0.2% |
N.D. |
Impurity B |
≤0.3% |
N.D. |
Impurity C |
≤0.2% |
N.D. |
Impurity D |
≤0.15% |
N.D. |
Impurity E |
≤0.3% |
N.D. |
Impurity I |
≤0.5% |
0.05% |
Any unspecified impurity |
≤0.10% |
Complies |
Total |
≤0.7% |
0.13% |
Ordinary impurities (USP) |
≤2.0% |
Complies |
Free thiol compounds (Ph.Eur.) |
≤0.05mL |
Complies |
Free mercapto compounds (USP) |
≤0.10mL |
Complies |
Chromium (Ph.Eur.) |
≤50ppm |
Complies |
Assay |
97.5%~102.0% |
100.90% |
HPLC (Ph.Eur.) |
97.5%~103.0% |
99.60% |
HPLC (USP) |
|
|
Residual solvent (In-house) |
≤3000ppm |
90ppm |
Methanol |
≤720ppm |
≤LOD (0.0046ppm) |
Tetrahydrofuran |
≤880ppm |
≤LOD (0.23ppm) |
DMF |
|
|
Particle size (In-house) |
95% ≤ 20 microns |
Complies |
Conclusion |
Compiles with EP7/USP35 |
5. Spironolactone Product Picture:
6. Spironolactone Applications:
Spironolactone is competitive inhibition of aldosterone drugs, drug itself is not active, role is diuresis
and endogenous competitive aldosterone antagonist and happen, belongs to the potassium diuretics.
7. Pharmaceutical Raw Material we supply:
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Can be used as pharmaceutical material |
8. Competitive Advantages:
Pre-sale service
1. Technical consultancy, to help customer know about the properties, features, quality, production and supply of the product they want.
2. Technical information and documents, such as COA, test report, sample etc.
3. Customers are welcome to visit our factory and negotiate with us at any time.
Sales service
1. Sign contract with customer, negotiating price, quality, delivery and other terms.
2.Answer the questions concerning properties, mechanism, application, quality, attention, usage etc. of the product.
3. Production schedule and on time delivery after signing contract.
After-sale service
1. Technical consultancy during use of the product.
2. Customer can return or exchange the merchandise with us if they need to change purchase plan due to some reasonable reasons, on condition that the product is not damaged.
3. If quality problems occur during normal use, please send us written information and documents, and we will respond within 24-48 hours.
Our R&D (research and development) center has around 1,000 square meters synthesis and testing laboratory, meets industrial standards, equipped with first class research facilities and powerful technical team.
Contact Person: Alex
Tel: 86-18171373082