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Ingredient Powder Quinidine CAS 56-54-2 for Antimalarial Usage

China Ingredient Powder Quinidine CAS 56-54-2 for Antimalarial Usage supplier
Ingredient Powder Quinidine CAS 56-54-2 for Antimalarial Usage supplier Ingredient Powder Quinidine CAS 56-54-2 for Antimalarial Usage supplier Ingredient Powder Quinidine CAS 56-54-2 for Antimalarial Usage supplier

Large Image :  Ingredient Powder Quinidine CAS 56-54-2 for Antimalarial Usage

Product Details:

Place of Origin: China
Brand Name: Skype: rdy705
Certification: Enterprise Standard
Model Number: ycwlb045@yccreate.com

Payment & Shipping Terms:

Minimum Order Quantity: 1G
Price: USD1
Packaging Details: Disguised Package
Delivery Time: Within 24 hours
Payment Terms: T/T, Western Union, MoneyGram and Bitcoin
Supply Ability: 50000000
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Detailed Product Description
CAS: 56-54-2 MF: C20H24N2O2
MW: 324.42 Usage: Weight Loss
Purity: 99%min. Properties: Powder
Payment: T/T, Western Union, MoneyGram, Bitcoin Delivery Time: Within 24 Hours
Delivery Mode: EXPRESS Door To Door

 

Ingredient Powder Quinidine CAS 56-54-2 for Antimalarial Usage

 

Product Name: Quinidine
Synonyms: (8R,9S)-6'-Methoxycinchonan-9-ol;(8r,9s)-quinidine;(95)-cinchonan-9-0;(9s)-6’-methoxycinchonan-9-ol;(9S)-6'-Methoxycinchonan-9-ol;2-Quinuclidinemethanol, alpha-(6-methoxy-4-quinolyl)-5-vinyl-;6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol;6'-Methoxycinchonan-9-ol
CAS: 56-54-2
MF: C20H24N2O2
MW: 324.42
EINECS: 200-279-0

 

Quinidine Chemical Properties


mp 168-172 °C(lit.)
alpha 256 º (c=1, EtOH)
storage temp. Store at -20°C
Water Solubility 0.05 g/100 mL (20 ºC)
Sensitive Light Sensitive
Merck 14,8060
BRN 91866
Stability: Stable. Incompatible with strong oxidizing agents.

 

Quinidine Usage And Synthesis


Chemical Properties white to light yellow crystal powde
Usage A dextrorotatory stereoisomer of Quinine. Antiarrhythmic (class IA). Antimalarial
Usage antiarrhythmic, antimalarial
General Description Crystals or white powder.
Air & Water Reactions Insoluble in water.
Fire Hazard Flash point data for Quinidine are not available. Quinidine is probably combustible.

 

Quinidine Side effects


Quinidine is also an inhibitor of the cytochrome P450 enzyme 2D6, and can lead to increased blood levels of lidocaine, beta blockers, opioids, and some antidepressants. Quinidine also inhibits the transport protein P-glycoprotein and so can cause some peripherally acting drugs such as loperamide to have central nervous system side effects, such as respiratory depression, if the two drugs are coadministered.

Quinidine can cause thrombocytopenia, granulomatous hepatitis, myasthenia gravis, and torsades de pointes, so is not used much today. Torsades can occur after the first dose. Quinidine-induced thrombocytopenia (low platelet count) is mediated by the immune system, and may lead to thrombocytic purpura.

Quinidine intoxication can lead to a collection of symptoms collectively known as cinchonism, with tinnitus (ringing in the ears) being among the most characteristic and common symptoms of this toxicity syndrome. Quinidine toxicity can also invoke episodes of Torsades de Pointes - a rapid and dangerous ventricular rhythm

 

Quinidine Other uses


A combination of dextromethorphan and quinidine has been shown to alleviate symptoms of easy laughing and crying (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis.[6] This drug is marketed as Nuedexta in the United States.

Intravenous quinidine is also indicated for treatment of Plasmodium falciparum malaria.[7] However, quinidine is not considered the first-line therapy for P. falciparum. The recommended treatments for P. falciparum malaria, according to the Toronto Notes 2008, are a combination of either quinine and doxycycline or atovaquone and proguanil (Malarone).

Quinidine sulfate is used in the treatment of atrial fibrillation in horses.

Quinidine-based ligands are used in AD-mix-β for Sharpless asymmetric dihydroxylation.

 

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Ingredient Powder Quinidine CAS 56-54-2 for Antimalarial Usage

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