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|Product Name:||Tamoxifen Citrate||Other Name:||Nolvadex|
1. Name: Toremifene citrate
2. CAS Registry Number:89778-27-8
3. Assay: 99%
4. Molecular Formula: C26H28ClNO.C6H8O7
5. Molecular Weight: 598.09
6. Melting Point: 158-164 ºC
7. Appearance: White or almost white powder
8. Usage: Used as pharmaceutical intermediate of Toremifene Citrate Tablets, which Apply to the treatment of post-menopausal women with estrogen-receptor positive or unknown metastatic breast cancer.
9. Storage: Preserve in tight containers, protected from humidity, keep in dry cool place
Toremifene citrate also known under its brand and trade name of Fareston is a member of a category, family, and class of drugs that are known as SERMs (Selective Estrogen Receptor Modulators). SERMs fall under an even broader category of drugs that are known as anti-estrogens, and the cousin family of SERMs (that also fall under anti-estrogens) are aromatase inhibitors, commonly abbreviated as AIs. SERMs include compounds such as Nolvadex and Clomid (Clomiphene Citrate). Aromatase inhibitors (AIs) include compounds such as Arimidex ) Aromasin, (Femara). Although the two fall under the category of anti-estrogens, they are both sub-categories that branch off into their own families, as SERMs and AIs differ greatly in their mechanism of action within the human body concerning how they control or block Estrogen.
Fareston acts as an anti-estrogen that will greatly aid in the combating of gynecomastia. By design, Toremifene Citrate will bind to the receptors in the chest, thereby preventing estrogen from binding and leading to the condition. Fareston is a fantastic SERM for this purpose; however, it's not always enough. Many men will need stronger protection, and stronger protection comes in the form of Aromatase Inhibitors (AI's). AI's function by inhibiting aromatase and lowering the body's total estrogen levels.
Toremifene is also agonistic to Estrogen receptors in other tissues in the body (within the liver in particular). This means that whileToremifene will act as an anti-estrogen in breast tissue and the hypothalamus, it will act as an Estrogen within the liver. This can have beneficial impacts especially during an anabolic steroid cycle, such as improving and shifting cholesterol levels into a more favorable range.
|Description||White or Almost White Crystalline Powder||White Powder|
|Loss On Drying||0.5%max||0.25%|
|Organic Volatile Impurities||meets the requirments.||Conforms|
|Residual Solvents||meets the requirments.||Conforms|
|Conclusion||The specification conform with USP32 standard|
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