Payment & Shipping Terms:
|Export Markets:||Global||Shipping Ways:||EMS, DHL, FedEx, TNT, UPS|
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
One of the advantages of follistatin as a therapeutic for inflammatory and fibrotic disorders is that it is a naturally occurring glycoprotein expressed by many cells in the body. Its primary function is to bind to and neutralize activins. Activins are a critical component of the innate immune response and in the development of fibrosis. Numerous studies have shown activin levels increase in the serum and various tissues in acute and chronic inflammatory diseases. Activins are also known to stimulate fibrosis and tissue repair and also mediate the fibrotic actions of other key growth factors. Follistatin therefore offers great potential for modulating inflammatory processes and preventing or resolving accompanying fibrosis.
Appearance : White to off-white crystalline powder or lumps
Specific Optical Rotation (c=0.5,10% HAc) :-50.0~-60.0°
Water Content(Karl Fischer) : ≤5.0%
Acetate Content(by HPLC) : ≤15.0%
Amino Acid Composition : ±10% of theoretical
Purity (by HPLC) :≥98.0%
Single Impurity(by HPLC) :≤1.0%
Peptide Content(by %N) : ≥80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
Bacterial Endotoxins : ≤5EU/mg
Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing myostatin. Scientists first identified follistatin while examining porcine (re: pig) follicular fluid in the ovaries.
Follistatin 315 primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a particular focus on activin, a paracrine hormone.
A study has also shown that increased levels of follistatin, by leading to increased muscle mass of certain core muscular groups, can increase life expectancy in cases of spinal muscular atrophy (SMA) in animal models.
It is also being investigated for its involvement in polycystic ovary syndrome (PCOS), though there is debate as to its direct role in this infertility disease.